Improving Therapeutic Delivery by Understanding Nanoparticle Interactions With Cells

In vivo assembly of epitope-coated biopolymer particles that induce anti-tumor responses

D Jenika, S Pounraj, D Wibowo, LM Flaxl, BHA Rehm, JD Mintern

2024-12-01

There is an unmet need for antigen delivery systems that elicit efficient T cell priming to prevent infectious diseases or for tre..

Constitutive Flt3 signaling impacts conventional dendritic cell function

KR Wilson, C Macri, JA Villadangos, JD Mintern

2024-07-01

The development of dendritic cells (DCs) depends on signaling via the FMS-like tyrosine kinase 3 (Flt3) receptor. How Flt3 signali..

Targeting dendritic cells to advance cross-presentation and vaccination outcomes

C Macri, D Jenika, C Ouslinis, JD Mintern

2023-07-01

Dendritic cells (DCs) are a complex network of specialised antigen-presenting cells that are critical initiators of adaptive immun..

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

H Liu, KR Wilson, AM Firth, C Macri, P Schriek, AB Blum, J Villar, S Wormald, M Shambrook, B Xu, HJ Lim, HEG McWilliam, AF Hill, LE Edgington-Mitchell, I Caminschi, MH Lahoud, E Segura, MJ Herold, JA Villadangos, JD Mintern

2022-12-01

The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, mo..

MHC class II ubiquitination regulates dendritic cell function and immunity

KR Wilson, D Jenika, AB Blum, C Macri, B Xu, H Liu, P Schriek, D Schienstock, L Francis, FV Makota, S Ishido, SN Mueller, MH Lahoud, I Caminschi, LE Edgington-Mitchell, JA Villadangos, JD Mintern

2021-11-01

MHC class II (MHC II) Ag presentation by dendritic cells (DCs) is critical for CD4⁺ T cell immunity. Cell surface level..

Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor

C Macri, H Morgan, JA Villadangos, JD Mintern

2021-11-01

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among ..

Dendritic cell Flt3 – regulation, roles and repercussions for immunotherapy

KR Wilson, JA Villadangos, JD Mintern

2021-10-01

Dendritic cells (DCs) are essential for initiating immune responses. Depending on the environment, the type of DC and the way in w..

Opportunities for innovation: Building on the success of lipid nanoparticle vaccines

J Huang, D Yuen, JD Mintern, APR Johnston

2021-10-01

Lipid nanoparticle (LNP) formulations of messenger RNA (mRNA) have demonstrated high efficacy as vaccines against SARS-CoV-2. The ..

In Vivo Quantification of Nanoparticle Association with Immune Cell Subsets in Blood

YR Ong, R De Rose, APR Johnston

2021-05-01

Nanoparticles offer great promise for more effective drug delivery. However, their particulate nature typically results in rapid s..

Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4 T Cells

H Liu, KR Wilson, P Schriek, C Macri, AB Blum, L Francis, M Heinlein, C Nataraja, J Harris, SA Jones, DHD Gray, JA Villadangos, JD Mintern

2020-09-01

MHC class II (MHC II) displays peptides at the cell surface, a process critical for CD4+ T cell development and priming. Ubiquitin..

Understanding Cell Interactions Using Modular Nanoparticle Libraries

GK Such, APR Johnston

2019-01-01

Nanoparticle delivery systems have significant potential to facilitate the delivery of novel therapeutics, such as proteins, DNA o..